Neoadjuvant FOLFIRINOX and Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer Patients

Inclusion Criteria

• •1. Histologically proven rectal adenocarcinoma.
• •2. Stages cT3 with risk of local recurrence, cT4, or N positive, M0 and for which a multidisciplinary meeting recommend TNT.
• •3. Resectable tumor, or considered as potentially resectable after CRT.
• •4. No distant metastases.
• •5. Patient eligible for surgery
• •6. World Health Organization (WHO)/Eastern Cooperative Oncology Group (ECOG) performance status 0/1.
• •7. No heart failure or coronary heart disease symptoms (even controlled).
• •8. No peripheral neuropathy \> grade 1.
• •9. No prior radiotherapy of the pelvis for any reason and no previous CT
• •10. No major comorbidity that may preclude the delivery of treatment
• •11. Adequate contraception in fertile patients.
• •12. Adequate hematologic function.
• •13 Adequate hepatic function.
• •14\. Signed written informed consent.