A Clinical Study to Evaluate the Efficacy of Activated Silk™ 27P-α in Subjects, Aged 35-65 Years of Age, to Improve the Signs of Aging

Exclusion Criteria

• •Subject is pregnant, nursing, or planning to become pregnant.
• •Subject is currently using medication likely to affect the response to investigational formulation.
• •Subject had a fever in the last 12 hours prior to the start of the study.
• •Subject has a pacemaker or significant medical history of hepatic, renal, cardiac, pulmonary, digestive, hematological, neurological, locomotor or psychiatric disease; cancer; multiple sclerosis; high blood pressure; thrombosis; phlebitis (inflammation of a vein); insulin-dependent diabetes; or any such related medical condition(s) that may interfere with the completion of the study.
• •The Subject used a form of retinol on their face in the past six months.
• •The Subject used any prescription skincare products on their face in the last six months.
• •The Subject has received any laser, chemical peel, or other facial resurfacing treatment such as microdermabrasion, dermablading or microneedling in the past four weeks.
• •The Subject received Botox, Dysport, other muscle relaxers or injectable skin fillers in the face during the past six months.
• •Subject has a known allergy or sensitivity to any ingredient in the aqueous skincare formulation provided for their use in the trial .
• •Subject is currently participating in another study utilizing facial products.
• •Subject is blind, visually impaired or decisionally impaired.