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A Clinical Study to Evaluate the Efficacy of Activated Silk™ 27P-α in Subjects, Aged 35-65 Years of Age, to Improve the Signs of Aging

A Clinical Study to Evaluate the Efficacy of Activated Silk™ 27P-α to Improve the Signs of Aging

NCT06804759•Victoria Collotta

Summary

A clinical study with approximately 40 subjects, aged 35-65 years of age, who must have crow's feet and at least one other type of facial fine lines/wrinkles in order to evaluate the efficacy of Activated Silk™ 27P-α to improve the signs of aging.

Eligibility

Age

35 - 65 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Healthy individuals, between the ages of 35 - 65 years of age, with no known medical conditions that interfere with study participation, are the priority.
•Subject has signed a written Informed Consent prior to Day -7.
•100% of subjects have crow's feet and at least one of the following: forehead lines/wrinkles (e.g. vertical lines between eyebrows, horizontal lines above the eyebrow), marionette lines, nasolabial folds.
•50% of subjects have self-perceived sensitive skin.
•20% of the subjects are not 100% caucasian.

Exclusion Criteria

•Subject is pregnant, nursing, or planning to become pregnant.
•Subject is currently using medication likely to affect the response to investigational formulation.
•Subject had a fever in the last 12 hours prior to the start of the study.
•Subject has a pacemaker or significant medical history of hepatic, renal, cardiac, pulmonary, digestive, hematological, neurological, locomotor or psychiatric disease; cancer; multiple sclerosis; high blood pressure; thrombosis; phlebitis (inflammation of a vein); insulin-dependent diabetes; or any such related medical condition(s) that may interfere with the completion of the study.
•The Subject used a form of retinol on their face in the past six months.
•The Subject used any prescription skincare products on their face in the last six months.
•The Subject has received any laser, chemical peel, or other facial resurfacing treatment such as microdermabrasion, dermablading or microneedling in the past four weeks.
•The Subject received Botox, Dysport, other muscle relaxers or injectable skin fillers in the face during the past six months.
•Subject has a known allergy or sensitivity to any ingredient in the aqueous skincare formulation provided for their use in the trial .
•Subject is currently participating in another study utilizing facial products.
+1 more criteria

Locations (1)

Evolved By Nature

Needham, Massachusetts, United States

Key Dates

Start Date

November 18, 2024

Primary Completion Date

December 20, 2024

Completion Date

January 1, 2025

Last Updated

February 3, 2025

Enrollment

ESTIMATED participants

Conditions

Skin Aging

Interventions

Investigational Facial Serum #1

OTHER

Investigational Facial Serum #2

OTHER

Investigational Facial Serum #3

OTHER

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 3, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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A Clinical Study to Evaluate the Efficacy of Activated Silk™ 27P-α in Subjects, Aged 35-65 Years of Age, to Improve the Signs of Aging

Inclusion Criteria

Exclusion Criteria

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