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Effects of Low Tidal Volume and Airway Pressure Release Ventilation on Lung Tissue Mechanics in ARDS Patients Under Mechanical Ventilation: A Prospective Randomized Crossover Study | Clinical Trials | Clareo Health

RECRUITINGNA

Effects of Low Tidal Volume and Airway Pressure Release Ventilation on Lung Tissue Mechanics in ARDS Patients Under Mechanical Ventilation: A Prospective Randomized Crossover Study

NCT06790875•Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to learn how low tidal volume ventilation (LTV) and airway pressure release ventilation (APRV) affect lung tissue mechanics in adults with ARDS. The main questions it aims to answer are: Does LTV or APRV improve lung tissue mechanics in patients with ARDS under mechanical ventilation? Researchers will compare LTV and APRV to see which ventilation mode works better for improving lung mechanics and patient safety.

Eligibility

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Meets the diagnostic criteria of the 2023 Global New Definition of ARDS.
•2. Age: 18-80 years.
•3. PaO2/FiO2 ≤ 200.
•4. Within 12 hours of invasive mechanical ventilation treatment.
•5. Obtain consent from the patient or their family members to participate in the study, and sign the informed consent form.

Exclusion Criteria

•1. Age \< 18 years or \> 80 years.
•2. Uncorrected shock of any type.
•3. Chronic obstructive pulmonary disease (COPD), pulmonary embolism, right heart failure, pulmonary hypertension, or severe arrhythmia.
•4. Contraindications for using Electrical Impedance Tomography (EIT) (extensive chest skin damage, infection, pacemaker implantation, implanted automatic defibrillator, etc.), pneumothorax, mediastinal emphysema, or large pleural effusion.
•5. Pregnant or breastfeeding women.
•6. Patients planned for ECMO treatment.
•7. Patients currently participating in or previously enrolled in other clinical studies.

Locations (1)

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China

Key Dates

Start Date

November 20, 2024

Primary Completion Date

November 20, 2025

Completion Date

November 20, 2025

Last Updated

January 24, 2025

Enrollment

ESTIMATED participants

Conditions

ARDS (Acute Respiratory Distress Syndrome)

Interventions

Airway Pressure Release Ventilation (APRV)

DEVICE

Contacts

Xiaojing Zou Professor

CONTACT

13995518630 13995518630@163.com

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 24, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Effects of Low Tidal Volume and Airway Pressure Release Ventilation on Lung Tissue Mechanics in ARDS Patients Under Mechanical Ventilation: A Prospective Randomized Crossover Study

Inclusion Criteria

Exclusion Criteria

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