REVEAL - Research With I-124 EVuzamitide to Elucidate Cardiac AmyLoidosis

This multicenter, open-label, single-arm, single-dose study will assess the sensitivity and specificity of I-124 evuzamitide for the diagnosis of cardiac amyloidosis compared to current clinical standards for diagnosis of cardiac amyloidosis. The study consists of (i) up to a 45-day screening period, (ii) a treatment emergent period that consists of a 1-day treatment visit and safety follow-up procedures through Day 30 ± 5 days, and (iii) a Standard of Truth (SoT) Diagnostic Evaluation Period that extends from the screening period (Day -45) until either the last cardiac amyloidosis diagnostic test is completed or through Day 60, whichever is earlier. Thus, the total participant duration is up to approximately 3.5 months. The study will enroll approximately 200 participants with suspected cardiac amyloidosis at approximately 20 United States clinical sites. I-124 evuzamitide is the only study intervention; neither reference therapy nor placebo will be administered. Potassium iodide (KI) will be given orally for 3 days beginning \>30 minutes prior to intravenous administration of study intervention. PET/CT scans will be obtained approximately 4 hours after administration of study intervention. Sensitivity and specificity of I-124 evuzamitide will be determined using the classification of participants based on visual evaluation of the PET/CT images and cardiac amyloid disease status based on the clinical truth standard. An independent Clinical Adjudication Committee with expertise in cardiology, amyloidosis, and/or cardiac imaging will review the information obtained during the diagnostic evaluation (e.g., clinical history and laboratories, EMB, extracardiac biopsy, ECHOs, CMR, and bone-avid tracer cardiac SPECT) to determine if the data support a diagnosis of cardiac amyloidosis. The clinical truth standard will be based on all available information provided to the Clinical Adjudication Committee by the diagnostic evaluation. Three independent readers who are blinded to all clinical data will review deidentified PET/CT images for the presence/absence of cardiac uptake of I-124 evuzamitide.