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Long-term Efficacy and Safety of Cagrilintide s.c. 2.4 mg in Combination With Semaglutide s.c. 2.4 mg (CagriSema 2.4 mg/2.4 mg) Once Weekly Versus Placebo in Participants With Obesity
This study will look at how well CagriSema helps people with obesity lose weight compared to a "dummy medicine". CagriSema is a new medicine developed by Novo Nordisk. CagriSema cannot yet be prescribed by doctors. The study has two parts: First part is called the main phase and will last for 2 years, and second part is called the extension phase and will last for 1 year. In the main phase participants will either get CagriSema or "dummy medicine". Which treatment participants get is decided by chance and is not known by participants or the study doctor. In the extension phase participants will get either CagriSema or slowly reduce participants dose of CagriSema if participants had CagriSema in the main phase. Which treatment participants get is decided by chance and is not known by participants or the study doctor in both phases. If participants had "dummy medicine" in the main phase, participants will get CagriSema in the extension phase. Like all medicines, the study medicine may have side effects.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Valley Clinical Trials
Covina, California, United States
Diablo Clinical Research, Inc.
Walnut Creek, California, United States
Yale University School Of Medicine
New Haven, Connecticut, United States
East West Medical Research Institute_Honolulu
Honolulu, Hawaii, United States
L-MARC Research Center
Louisville, Kentucky, United States
StudyMetrix Research LLC
City of Saint Peters, Missouri, United States
Spartanburg Medical Research
Spartanburg, South Carolina, United States
Holston Medical Group_Bristol
Bristol, Tennessee, United States
North Texas Endocrine Center
Dallas, Texas, United States
Washington Cntr Weight Mgmt
Arlington, Virginia, United States
Start Date
February 10, 2025
Primary Completion Date
August 28, 2028
Completion Date
October 31, 2028
Last Updated
January 20, 2026
400
ESTIMATED participants
Cagrilintide
DRUG
Semaglutide
DRUG
Placebo cagrilintide
DRUG
Placebo semaglutide
DRUG
Lead Sponsor
Novo Nordisk A/S
NCT07472881
NCT01143454
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
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