Post-menopausal with natural (no bilateral oophorectomy) amenorrhea for at least 1 year
If using hormone replacement therapy, limit of a maximum of 3 years of treatment but not within the last 6 months.
Diagnosis of stage I, II, or III breast cancer
Hormone receptor positive breast cancer
HER negative (ER+/PR+/HER-) breast cancer
Breast cancer patients \~1 post-diagnosis who have received aromatase inhibitor therapy
Breast cancer patients \~5 and \~10 years post-diagnosis who have received aromatase inhibitor therapy for at least 2 years
Received surgery/radiation therapies
Control group:
Biologically female
Post-menopausal with natural (no bilateral oophorectomy) amenorrhea for at least 1 year
If using hormone replacement therapy, limit of a maximum of 3 years of treatment but not within the last 6 months.
You may not be if
Previous treatment using tamoxifen endocrine therapy in a pre-or peri-menopausal setting
Major signs or symptoms of cardiovascular diseases, diabetes, or renal disease (taken from the American College of Sports Medicine's Guidelines for Exercise Testing and Prescription 11th edition Table 2.1: pain or discomfort in the chest, neck, jaw, arms with rest or exercise, shortness of breath at rest or with mild exertion, dizziness or syncope, loss of balance or passing out, ankle edema, palpitations or tachycardia, intermittent claudication, known heart murmur, unusual fatigue with usual activities.)
American Heart Association's absolute or relative contraindications for symptom-limited maximal exercise testing (myocardial infarction, aortic or coronary artery stenosis, heart failure, pulmonary embolism or deep vein thrombosis, inflammation of the heart (myocarditis, pericarditis, and/or endocarditis), uncontrolled cardiac arrythmia, advanced or complete electrical heart block, stroke or transient ischemia attack, blood pressure \>200mmHg/100mmHg, a cancer diagnosis other than skin cancer)
Unable to provide informed consent or communicate in English
Mobility limitations to exercise testing (i.e., wheelchair, walker use, limp impeding walking)
Extreme claustrophobia
Clareo Health | Chronic Impacts of Endocrine Therapy on Cardiovascular and Brain Health Outcomes in Breast Cancer
