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Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy | Clinical Trials | Clareo Health

COMPLETEDPHASE4

Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy

Comparison of Hemodynamic Effect of Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy: a Randomized Controlled Trial.

NCT06772727•Cairo University

View on ClinicalTrials.gov

Summary

Lidocaine-based anesthesia had been recently reported as a successful regimen for induction of anesthesia in elderly population with better hemodynamic profile than opioid-based induction. The investigators hypothesize that lidocaine-based induction of anesthesia would provide superior hemodynamic profile compared to conventional opioid-based induction of anesthesia in emergency laparotomy.

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Adult patients
•2. Both gender
•3. American Society of Anesthesiologists (ASA) class I-III undergoing emergency laparotomy.

Exclusion Criteria

•1. Patient refusal
•2. Severe cardiac morbidities (impaired contractility with ejection fraction \< 45%, heart block, arrhythmias, tight valvular lesions)
•3. Baseline mean arterial pressure \<75 mmHg
•4. Patients on vasopressor infusion,
•5. Patients with high shock index (heart rate / systolic blood pressure \>1)
•6. Pregnant or lactating women,
•7. Allergy of any of the study drugs
•8. Uncontrolled hypertension
•9. Opioid drug abusers
•10. Patients with increased intracranial tension

Locations (1)

Faculty of Medicine, Cairo University

Cairo, Egypt

Key Dates

Start Date

February 1, 2025

Primary Completion Date

October 30, 2025

Completion Date

October 30, 2025

Last Updated

March 5, 2026

Enrollment

149

ACTUAL participants

Conditions

Post-induction HypotensionLidocaineOpioidEmergency Laparotomy

Interventions

Lidocaine

DRUG

Fentanyl

DRUG

Propofol

DRUG

Succinyl choline

DRUG

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 5, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy

Inclusion Criteria

Exclusion Criteria

Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)

Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery

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