Stereotactic Radiosurgery Versus Radiofrequency Ablation for Primary Liver Cancer

Inclusion Criteria

• •1. Prior to implementing any trial-related procedures, written informed consent must be signed;
• •2. Age ≥ 18 years and ≤ 75 years;
• •3. Child-Pugh score ≤ 7;KPS score ≥ 70;
• •4. The patient must be clearly diagnosed with hepatocellular carcinoma, usually confirmed through imaging (CT, MRI) or histological examination (biopsy);
• •5. The tumor is located near major blood vessels/diaphragm/liver capsule/liver hilum;
• •6. Surgically assessed as inoperable hepatocellular carcinoma or recurrence of primary hepatocellular carcinoma within 2 years after radical treatment;
• •7. According to the criteria for evaluating the efficacy of solid tumors, there should be at least one measurable lesion by imaging, with the lesion size not exceeding 5 cm; total number of lesions ≤ 3;
• •8. No previous anti-tumor treatment;
• •9. Normal liver (liver volume minus tumor volume) is sufficient;
• •10. Normal major organ functions, including blood routine tests \[absolute neutrophil count (ANC) ≥ 1.5 × 10\^9, platelets ≥ 70 × 10\^9, hemoglobin ≥ 80 g/L\], liver function tests \[bilirubin \< 3.0 mg/dL, international normalized ratio (INR) \< 1.7, albumin ≥ 2.8 g/dL, aspartate transaminase (AST)/alanine transaminase (ALT) \< 6\], serum creatinine \< 1.5 times the upper limit of normal, or creatinine clearance ≥ 60 mL/min;
• •11. Stable respiration for more than 10 minutes;
• •12. Expected survival time \> 2 years.