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PRF Membrane and Recovery After Periapical Surgery: A 3D Imaging Study | Clinical Trials | Clareo Health

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PRF Membrane and Recovery After Periapical Surgery: A 3D Imaging Study

Evaluation of PRF Membrane in Postoperative Recovery: A Preliminary Study Using 3D Imaging in Periapical Surgery

NCT06739200•Semmelweis University

Summary

The goal of this clinical trial is to determine whether a PRF (platelet-rich fibrin) membrane helps improve recovery after periapical surgery in adults. The main questions it seeks to answer are: Does the use of a PRF membrane reduce swelling and pain after surgery? Does the use of a PRF membrane improve healing as observed on 3D imaging? Researchers will compare the outcomes of participants who receive a PRF membrane during surgery with those who do not, to assess whether the PRF membrane improves recovery. Participants will: Undergo periapical surgery with or without the use of a PRF membrane. Have swelling and pain assessed at specific time points after surgery. Participate in 3D imaging scans to evaluate healing. Participants will: Undergo periapical surgery with or without the use of a PRF membrane. Have swelling and pain measured at specific time points after surgery. Take part in 3D imaging scans to evaluate healing.

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Adults aged 20-65 years, both male and female.
•Diagnosed with periapical disease, including periapical cysts or granulomas.
•Requiring periapical surgery as part of their treatment plan.
•Presenting a tooth needing endodontic surgery with periradicular lesions of strictly endodontic origin.
•Size of the bone crypt between 6 mm and 12 mm.
•Non-surgical retreatment considered unfeasible or previously failed.
•Apical root canal free from posts over a length of at least 6 mm.
•Adequate coronal restoration without coronal leakage.
•Willing and able to provide written informed consent.
•Capable of attending follow-up visits and participating in required assessments.
+2 more criteria

Exclusion Criteria

•Patients with systemic conditions affecting healing, such as:
•* • Uncontrolled diabetes mellitus.
•* • Autoimmune disorders.
•* • Chronic inflammatory diseases.
•Pregnant or breastfeeding individuals.
•Use of medications or therapies that may interfere with healing, including:
•* • Bisphosphonates.
•* • Immunosuppressants.
•* • Radiotherapy.
•* • Oncological therapies (e.g., chemotherapy, immunotherapy).
+11 more criteria

Locations (1)

Semmelweis University, Department of Oral and Maxillofacial Surgery

Budapest, Mária Utca 52, Hungary

Key Dates

Start Date

September 4, 2023

Primary Completion Date

November 5, 2024

Completion Date

December 4, 2024

Last Updated

December 18, 2024

Enrollment

ACTUAL participants

Conditions

Periapical DiseasesRadicular CystGranulomaPostoperative ComplicationsPain, Postoperative

Interventions

Platelet-Rich Fibrin (PRF) Membrane

PROCEDURE

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RECRUITINGPHASE2

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Common Variable Immunodeficiency (CVID)Primary Immune Regulatory Disorder+13 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 18, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

PRF Membrane and Recovery After Periapical Surgery: A 3D Imaging Study

Inclusion Criteria

Exclusion Criteria

Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease (CGD) With an Alemtuzumab, Busulfan and TBI-based Conditioning Regimen Combined With Cytokine (IL-6, +/- IFN-gamma) Antagonists

Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)

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