This is Comparative Study in Normal Healthy Subjects to Evaluate Pharmacokinetics, Safety, Tolerability of Bmab 1200 -Autoinjector (AI) After Single Subcutaneous Injection (45 mg) in Comparison With Bmab 1200 -Prefilled Syringe (PFS).

Exclusion Criteria

• •a. Known hypersensitivity or idiosyncratic reaction to ustekinumab or any excipients or any related drug or any substance (specifically any biologic product or the constituents of Bmab 1200).
• •b. Known hypersensitivity to host cell \[ murine myeloma cell or Chinese hamster ovary cells\] derived proteins, latex), food, or other substance.
• •c. History or presence of any disease or condition which might compromise the haemopoietic, renal, hepatic, endocrine, pulmonary, central nervous, cardiovascular, immunological, dermatological, gastrointestinal, or any other body system.
• •d. Use or intend to use any medications/products known to alter drug absorption, metabolism, or elimination processes.
• •e. Use or intend to use any prescription medications/products or other acceptable concomitant Medications within 30 days prior to dosing or slow-release medications/products considered to still be active within 14 days prior to check-in.
• •f. Use or intend to use any nonprescription medications/ products, including vitamins, minerals, and phytotherapeutic/ herbal/ plant-derived preparations within 7 days prior to check-in.
• •g. Use of any vaccine from 4 weeks prior to screening.
• •h. The QTc interval more than 450 ms for male and more than 460 ms for female at the time of screening.
• •i. Any history or presence of asthma (including aspirin-induced asthma) or nasal polyp or NSAIDs induced urticaria.
• •j. A recent history of harmful use of alcohol (less than 2 years), or consumption of alcohol or alcoholic products within 48 hours prior to receiving study drug.
• •k. Smokers, or who have smoked within the last six months prior to the start of the study.
• •l. The presence of clinically significant abnormal laboratory values during screening.
• •m. Use of any recreational drugs or history of drug addiction or testing positive in pre-study drug scans.
• •n. History or presence of seizure or psychiatric disorders.
• •o. A history of difficulty with donating blood.
• •p. Donation of blood (1 unit or 350 mL) or plasma/ platelets in the last 90 days prior to screening until 3 months after the end of study visit.
• •q. Participation in a clinical study involving the administration of an investigational drug in the past 90 days or 5 half-lives (whichever is longer), prior to dosing.
• •r. A positive hepatitis screen including hepatitis B surface antigen and/or HCV antibodies.
• •s. A positive test result for HIV antibody (I \&/or 2).
• •t. Current history of active infections, including significant localized infections, cough or fever, or current /previous history of recurrent or chronic infections. (At screening and within 1 week prior to study drug administration).
• •u. History of active tuberculosis (TB) or presence of active or latent TB. A positive result for IGRA (Interferon Gamma Release Assay) test at screening.
• •v. Known history of previous exposure to ustekinumab or ustekinumab biosimilar, or any IL-12 or IL-23 monoclonal antibodies, approved or investigational.
• •w. Consumption of grapefruit or grapefruit products within 72 hours prior to dosing.
• •x. An unusual diet, for whatever reason (for example, fasting, high potassium or low sodium), for four weeks prior to receiving the study medicine. In any such case, subject selection will be at the discretion of the Principal Investigator.
• •y. Ingestion of poppy seed-containing foods or beverages within 7 days prior to check-in.
• •z. Receipt of blood products within 2 months prior to check-in. aa. Poor peripheral venous access.