Study of Transcatheter Aortic Valve Replacement With A² Flex and Commissural Alignment Technology in Severe Aortic Stenosis

Exclusion Criteria

• •The left and right coronary ostiums originate from the junctional zone or from both coronary ostiums;
• •previous CABG history;
• •Coronary ostial lesions（PCI or not）;
• •Prior aortic valve prosthesis implantation (interventional/surgical, bioprosthetic/mechanical);
• •Spoor peripheral arterial condition precluded transfemoral TAVR;
• •Severe coronary stenoses requiring intervention for which concomitant PCI is not possible;
• •Concomitant diseases requiring cardiac surgery;
• •Other serious diseases that may reduce life expectancy to less than 12 months (e.g. clinically recurrent or metastatic cancer, congestive heart failure, etc.);
• •contraindications to conventional cardiac catheterization, such as intracardiac thrombosis, infection, outflow obstruction, hypertrophic cardiomyopathy, etc;
• •other surgical anatomical contraindications, such as the risk of coronary artery occlusion;
• •clinically significant active bleeding
• •platelet count \< 30×10/ L;
• •participating in other drug or medical device clinical studies that have not yet been completed ;
• •considered inappropriate by the investigator to participate in the clinical study.