Rifaximin SSD in Dementia Trial

Exclusion Criteria

• •Dementia not due to AD or VaD
• •Clinically significant agitation or aggression (requiring treatment with antipsychotic medication)
• •Delusions and/or hallucinations
• •Severe psychopathology including major depression
• •Unstable, severe, or poorly controlled medical conditions evident from physical examination or clinical history
• •Visual and/or hearing disorder that prevents completion of neuropsychologic evaluations.
• •Diarrhea
• •Hypersensitivity to rifaximin, components of rifaximin,
• •and any rifamycin antimicrobial agent
• •Antibiotic use in the prior 6 months
• •Taking medications that interact with Rifaximin. P-glycoprotein (P-gp) inhibitor treatment is permitted as long as the use of P-gp inhibitors is discussed with the investigator.
• •History of alcohol and/or drug abuse
• •Participation in another investigational drug trial in the last 30 days