QR12000 Compound Tablets in Patients with Moderate to Severe Essential Hypertension

Exclusion Criteria

• •1. History or evidence of a secondary form of hypertension.
• •2. History of peripheral arterial occlusive disease and Raynaud's syndrome.
• •3. History of hyperthyroidism.
• •4. History of hypotension.
• •5. History of angioedema, drug-related or otherwise.
• •6. Suffered by severe cerebrovascular disease within 1 year prior to screening.
• •7. Suffered by severe heart disease within 1 year prior to screening
• •8. History of severe or malignant retinopathy.
• •9. History of aortic aneurysm or dissection, cardiac surgery, or percutaneous coronary intervention within 1 year prior to screening.
• •10. History of malignant tumor within 5 years prior to screening.
• •11. Poorly controlled diabetes prior to screening
• •12. History of severe autoimmune diseases.
• •13. History of severe mental disorder.
• •14. Clinically significant laboratory abnormalities.
• •15. History of allergy to the test drug, active control drug, or drugs similar to the test drug and positive control drug or related excipients.
• •16. Undergone gastrointestinal surgery that could significantly alter drug absorption, distribution, metabolism, and excretion, or with severe gastrointestinal diseases, dysphagia, or recurrent vomiting that causes difficulty in eating or taking medication.
• •17. Intolerance to the run-in period.
• •18. Poor medication compliance or other non-compliance during run-in period.
• •19. Participated in any interventional clinical trial within 3 months prior to screening, plan to participate in another clinical trial during the period of this trial, or plan to participate in another clinical trial within 1 month after the end of this trial.
• •20. History of alcohol abuse within 6 months prior to screening or evidence of drug abuse.
• •21. Not agree or unable to comply with the restrictions on concomitant treatment during the study.
• •22. Pregnancy test positive, lactating women, or women planning to become pregnant.
• •23. High-altitude workers or large motor vehicle drivers and other professionals engaged in hazardous mechanical operations.
• •24. Other conditions that by the investigator's discretion may interfere with efficacy or safety assessment of the study, or pose a great risk to the subject.