Effect of Intermittent Hypoxia on Ventilatory Endurance in Healthy Volunteers

Inclusion Criteria

• •Non-excessive coffee drinker (\< 3 espressos / day)
• •Non-smoker or weaned for 3 months and total consumption \< 10 packs/year
• •With a BMI within \]18 - 25\[ kg/m².
• •Benefiting from a Social Security plan or benefiting from one through a third party
• •Giving free, informed and signed consent, after receiving clear and fair information about the study.
• •History of respiratory or ENT disease (asthma, chronic bronchitis, COPD, respiratory allergy, swallowing disorders, oropharyngeal malformation, obstructive or central sleep apnea-hypopnea syndrome, alveolar hypoventilation syndrome)
• •Respiratory, cardiovascular, muscular, neurological or diabetic pathology or disorders
• •Raynaud's disease/syndrome
• •History of epilepsy or history of malaise suggestive of epilepsy
• •Psychiatric history requiring hospitalization
• •Liver failure
• •Renal insufficiency
• •History of acute mountain sickness (presence during or after a stay at altitude of symptoms of vertigo, headache, nausea/vomiting and incapacitating fatigue: Lake Louise score \> 0)
• •History of migraines
• •Taking medications that interfere with respiratory function or cardiovascular function, or psychotropic drugs ( anxiolytic, sedative, antidepressant, neuroleptic, muscle relaxant, etc.).
• •Alcohol or drug dependence
• •Anemia, sickle-cell anemia
• •SpO2 \< 97% at rest in room air
• •Currently participating in another clinical study
• •Protected persons within the meaning of article L1121-5 to 8 (persons benefiting from enhanced protection, i.e. minors, persons deprived of their liberty by a judicial or administrative decision, pregnant or breast-feeding women, persons staying in a health or social establishment, adults under legal protection, and patients in emergency situations). - Women with childbearing capacity who do not have effective contraception (hormonal/mechanical: oral, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy).
• •Incidental finding of acute mountain sickness (Lake Louise score \>0)
• •Pregnant woman (incidental finding)
• •Persistence of average sleep time \< 6h
• •Non-reversible deterioration in volunteer's state of health within study period
• •Electroencephalogram signal unusable