Immunotherapy with Autologous Tregs in T1DM

Exclusion Criteria

• •The condition of diabetic ketoacidosis has not been controlled;
• •Severe allergic constitution;
• •Known or suspected tumor;
• •Acute pancreatitis, and severe heart, liver, kidney, rheumatic immune, respiratory, nervous or infectious diseases.
• •Suffering from gestational diabetes mellitus, single gene mutation diabetes mellitus, diabetes mellitus caused by pancreatic damage or other secondary diabetes mellitus (such as diabetes mellitus caused by Cushing's syndrome, thyroid dysfunction or acromegaly, etc.);
• •Women who are pregnant or have a pregnancy plan before and after treatment, and women who are breastfeeding.
• •Mental illness, alcohol or drug abuse, unable to cooperate with treatment;
• •According to the judgment of the investigator, there are other clinical conditions that may endanger the safety of the subjects.