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The Effect of Sevoflurane on Haemodynamics | Clinical Trials | Clareo Health

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COMPLETEDNCT06707077

The Effect of Sevoflurane on Haemodynamics

Cardiac output (CO) is measured using Mostcare. Mean systemic filling pressure (MSFP) and vascular resistances are calculated using venous return curves constructed by measuring steady-state arterial ...

Lead sponsor: Children's Hospital of Fudan University•1 locations•View source on ClinicalTrials.gov

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Lead Sponsor

Children's Hospital of Fudan University

Tracheal intubation is performed after anesthesia induction with sevoflurane. Radial arterial is cannulated and pressure transducer is connected to MostCare (core technique PRAM). HR, MAP, CVP, CO, SVR, PPV, and dp/dt are recorded at three incremental levels of targeted sevoflurane concentrations. MSFP and vascular resistances are calculated.

Age

3 - 10 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•American Association of Anesthesiologists (ASA)physical status score I-III
•major elective surgery that dictates the use of invasive hemodynamic monitoring including CVP and continuous arterial blood pressure monitoring.

Exclusion Criteria

•symptomatic peripheral vascular disease or pulmonary disease
•aberrant cardiovascular anatomy
•significant valvular regurgitation
•severe arrhythmia

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: March 12, 2025Terms

Trial snapshot

StatusCOMPLETED

Phase—

Enrollment40

Start dateDec 2024

Last updatedMar 12, 2025

Condition

Sevoflurane Cardiac Output Venous Return Vascular Resistance

Locations shown

Children's hospital of Fudan university

Shanghai

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 12, 2025Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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