Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder

Exclusion Criteria

• •psychiatric medication use in the past 2 months
• •substance use disorder in the past 6 months
• •lifetime history of psychotic disorder including schizophrenia
• •schizoaffective disorder, major depression with psychotic features
• •history of psychiatric disorder other than PMDD in past year
• •active suicidal ideation with plan or attempt in past 6 months
• •steroid hormone or hormonal contraceptive use (except levonorgestrel as emergency contraceptive) in past 2 months
• •pregnancy in past 6 months
• •history of brain injury
• •current or history of endocrine disorder including uncontrolled diabetes or thyroid disease
• •BMI\>40
• •History of arrythmias, severe liver impairment, history of seizure disorder
• •If currently taking the following meds: methylene blue, linezolid
• •Other prohibited concomitant meds are Monoamine oxidase inhibitors (MAOIs), pimozide, and disulfiram