Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo
A.O.U. Città della Salute e della Scienza
Neurologia Arzignano AULSS8 Berica
Azienda Ospedaliero-Universitaria di Modena
Age
50–80
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
consecutive subjects with a clinical indication to undergo lumbar puncture for the determination of cerebrospinal fluid biomarkers of amyloidosis, tauopathy, and neurodegeneration during diagnostic assessments for cognitive impairment (as per clinical practice)
informed consent form signed by patient or caregiver
You may not be if
Age under 50 or over 80 years
Non-native Italian speakers
History of previous or concurrent neurological diseases that could impact cognition (e.g., severe cerebrovascular accidents, brain tumors, traumatic injuries, etc.)
History of major psychiatric disorders that could affect cognitive abilities
History of alcohol use disorder
Medical conditions that may interfere with cognitive functions (e.g., renal or hepatic failure, respiratory diseases, hypothyroidism, vitamin B12 deficiency, etc.)
Uncompensated systemic disease with instability and significant organ failure
Contraindications to lumbar puncture (e.g., presence of spinal malformations or current use of anticoagulant therapy)
Previous or current participation in experimental studies involving amyloid-targeting agents
