Diagnosis of MDD or bipolar depression and currently in a major depressive episode
Score of at least 29 on the MADRS (at least moderate depression)
You may not be if
Hypersensitivity to celecoxib, minocycline, tetracyclines, sulfonamides, aspirin, other NSAIDs, or any component of the formulation; previous asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
History of myocardial infarction or current cardiac condition
Heptic impairment, heart failure, severe renal impairment, recent GI bleed, history of peptic ulcer disease, anemia or any other contraindication for celecoxib or minocycline
Poor CYP2C9 metabolizer
Currently taking medications that interact with celecoxib (digoxin, antihypertensives, diuretics, anticoagulant or anti-platelet treatment, including aspirin), or minocycline (isotretinoin, ergot alkaloids) without providing physicians approval
Use of herbs, drugs, or medications with anti-inflammatory or immunomodulatory properties (within 5 half-lives of starting celecoxib or minocycline treatment)
Unlikely to tolerate medication washout or the medication-free period following washout.
Participant considered at significant risk for suicide.
Electroconvulsive therapy (ECT) within 1 month
High potential for excessive drug/alcohol use during the treatment period (excluding nicotine or cannabis)
Significant active physical illness or neurological deficit that may affect brain functioning.
If participant is currently pregnant, breastfeeding, or planning to conceive during the course of study participation.
Need for medications that control mania.
Clareo Health | Stony Brook Medicine Anti-Inflammatory Trial
