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Characterizing the EEG Signature of Fentanyl and Its Association With Drug Liking | Clinical Trials | Clareo Health

ENROLLING_BY_INVITATION

Characterizing the EEG Signature of Fentanyl and Its Association With Drug Liking

NCT06699953•Stanford University

Summary

The goal of this study is to characterize an electroencephalogram (EEG) biomarker for fentanyl and understand where this signal is coming from in the brain. The investigators also aim to understand how this EEG biomarker is connected to patient perception to drug liking.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. 18 years old or above (male and female)
•2. American Society of Anesthesiologists (ASA) physical status classification of I, II or III
•3. Candidates scheduled for general surgical procedures under general anesthesia and receive fentanyl for surgery

Exclusion Criteria

•1. Craniofacial abnormalities
•2. Known or suspected difficult intubation or mask ventilation
•3. Known or suspected need for rapid sequence induction and intubation
•4. Body mass index above 45 kg/m2
•5. Allergies to fentanyl
•6. History of obstructive sleep apnea requiring CPAP
•7. History of obstructive or restrictive lung disease
•8. Opiate use within 24 hours
•9. History of opiate abuse within the last 3 years
•10. Known or suspected severe chronic pain condition that require use of opiates or limit daily activities
+1 more criteria

Locations (1)

Stanford Hospital

Palo Alto, California, United States

Key Dates

Start Date

February 4, 2025

Primary Completion Date

June 30, 2026

Completion Date

December 31, 2026

Last Updated

December 17, 2025

Enrollment

ESTIMATED participants

Conditions

Brain Activity Related to Opioid AdministrationBrain Activity Related to Drug Liking

Interventions

Observational study in patients receiving fentanyl for surgery

OTHER