This is an open-label, single dose, non-randomised, parallel group, Phase I study to assess the pharmacokinetics, safety, and tolerability of AZD4144 in male and female participants with severe renal impairment and end-stage kidney disease (ESKD) compared with healthy control participants.
The study will comprise of:
* A Screening Period of 21 days.
* Cohort 1, 2, 4, and 5: a single Treatment Period with an in-clinic period of 7 days.
* Cohort 3: two Treatment Periods each with an in-clinic period of 7 days, and a washout period of 6 days after the in-clinic treatment period.
* A Follow-up visit 7 days following discharge.