To evaluate the subjective tolerance of high-intensity NPPV and low-intensity NPPV patients in a conscious state by two questionnaire surveys; To assess tolerance of high-intensity NPPV and low-intensity NPPV patients patient in sleeping status by PSG monitoring.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
AECOPD confirmed by the 2019 criteria of the Global Initiative for Chronic Obstructive Lung Disease (GOLD);
Arterial pH \<7.35 and PaCO2 \>45 mmHg at screening entry;
PaCO2 \>45 mmHg after a 6-hour trial of low-intensity NPPV.
You may not be if
Age \<18 years
Excessive respiratory secretions with weak cough
Upper airway obstruction
Recent oral, facial, or cranial trauma or surgery
Recent gastric or esophageal surgery
Presence of restrictive ventilatory dysfunction (eg, consolidation or removal of at least one pulmonary lobe, massive pleural effusion, chest wall deformity, continuous strapping with thoracic or abdominal bandage, or severe abdominal distension)
Active upper gastrointestinal bleeding
Cardiac or respiratory arrest
Arterial oxygen tension/fraction of inspired oxygen (PaO2/FiO2) \<100 mmHg
Pneumothorax
Obvious emphysematous bullae confirmed by chest CT scan
Ventricular arrhythmia or myocardial ischemia
Severe hemodynamic instability (mean arterial pressure \<65 mmHg)
Severe metabolic acidosis (pH \<7.20 and bicarbonate \<22 mmol/L)
Refusal to receive NPPV or give informed consent
Prior endotracheal intubation or tracheostomy during the current hospitalization
A do-not-intubate order
Clareo Health | Impact of HI-NPPV Vs LI-NPPV on Tolerance Among AECOPD Patients
