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In this study, consecutive 600 patients with LAGC(cT2-4NanyM0) who underwent NACT between Jan. 2010 and Jun. 2022 were identified from two tertiary hospitals. The mCXI was constructed based on Random Forest model, calculated as (post-NACT L3 subcutaneous adipose tissue area \[SAT\])×(post-NACT serum albumin \[ALB\])/(post-NACT platelet count \[PLT\]). Patients were categorized into two subgroups: mCXI-low and mCXI-high. mCXI is associated with the overall prognosis in patients with locally advanced gastric cancer underwent neoadjuvant chemotherapy, is superior to traditional CXI, and may serve as a decision-making tool for guiding personalized postoperative adjuvant chemotherapy.
This is a multicenter retrospective cohort study
Age
18 - 84 years
Sex
ALL
Healthy Volunteers
No
Fujian Medical University Union Hospital
Fuzhou, Fujian, China
Start Date
December 1, 2023
Primary Completion Date
June 30, 2024
Completion Date
July 13, 2024
Last Updated
November 14, 2024
600
ACTUAL participants
Lead Sponsor
Fujian Medical University
NCT04550494
NCT04704661
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