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Physical Rehabilitation of Older Persons Following a Community-Acquired Infection Hospitalization - A Randomised-Controlled Trial | Clinical Trials | Clareo Health

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Physical Rehabilitation of Older Persons Following a Community-Acquired Infection Hospitalization - A Randomised-Controlled Trial

Physical Rehabilitation of Older Persons Following a Community-Acquired Infection Hospitalization: A Feasibility Study

NCT06689280•Nordsjaellands Hospital

View on ClinicalTrials.gov

Summary

Community-acquired infections such as community-acquired pneumonia (CAP) and urinary tract infection (UTI) remain leading causes of hospitalization and death due to infections in older persons in Europe. Hospitalization often results in further disabilities and frailty for older and frail individuals, from which some may never recover. Physical activity is well-established as a cornerstone in the primary prevention and treatment of several noncommunicable diseases. However, there is currently no established rehabilitation model following a pneumonia or other infection, nor is there any evidence to support the impact of rehabilitation on the mental and physical health of older and frail individuals following a pneumonia hospitalization or other infection. The aim of the feasibility study is to evaluate a patient-centered and individualized exercise intervention that is kick-started during hospitalization and continued for 3 months after discharge with video-supervised home-based exercise training to patients hospitalized with CAP or UTI compared to standard care with regard to safety, clinical outcomes, patients' perception, functional ability, organizational aspects, and economic aspects.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients aged ≥65 years or 18-64 years if the presence of at least one chronic disease (e.g., diabetes, COPD, heart failure, etc.)
•Suspicious of a lower respiratory tract infection AND
•Presence of one or more symptoms of a lower respiratory tract infection such as fever ≥38.3°C, hypothermia \<35.0°C, new onset of cough, pleuritic chest pain, dyspnea, or altered breath sounds on auscultation.
•Positive urine nitrate test and/or leukocyturia as depicted by positive esterase test or microscopy AND
•Presence of one or more symptoms of urinary tract infection such as dysuria, urgent or frequent urination, perineal or suprapubic pain, costo-vertebral tenderness or flank pain, fever (ear or rectal temperature of ≥38.2°C or axillary temperature of ≥38.0°C), or history of feeling feverish with shivering or rigors in the past 24 hours.
•Functionally independent before hospitalization and expected to be discharged to their own homes.
•Signed informed consent.

Exclusion Criteria

•Hospitalization within the past 14 days.
•Inability to participate in the study due to dementia, paralysis, or other disorders.
•Severe aortic valve stenosis or terminal illness.
•Unstable cardiac arrhythmic disease.
•High risk for non-adherence as determined by screening evaluation.
•Already participating in regular exercise training.
•Unable to understand Danish.
•Unwilling or unable to give informed consent.

Locations (3)

Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital

Hillerød, Denmark

Department of Infectious Diseases, Copenhagen University Hospital, Amager-Hvidovre

Hvidovre, Denmark

Department of Respiratory Medicine, Copenhagen University Hospital, Amager-Hvidovre

Hvidovre, Denmark

Key Dates

Start Date

January 1, 2026

Primary Completion Date

March 31, 2029

Completion Date

December 31, 2029

Last Updated

December 2, 2025

Enrollment

460

ESTIMATED participants

Conditions

Community-acquired PneumoniaUrinary Tract Infections

Interventions

Video-supervised home-based exercise training

BEHAVIORAL

Contacts

Birgitte Lindegaard, MD, PhD

CONTACT

+4548293874 birgitte.lindegaard.madsen@regionh.dk

Camilla Koch Ryrsø, MSc, PhD

CONTACT

+4548293261 camilla.koch.ryrsoe.01@regionh.dk

A Study of LBP-EC01 in the Treatment of Acute Uncomplicated UTI Caused by Drug Resistant E. Coli (ELIMINATE Trial)

NCT05488340

Urinary Tract Infections

View study

RECRUITING

The Fever Clinic Acute Respiratory Cohort

NCT07278700

Acute Respiratory InfectionsFebrile Illnesses+3 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 2, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Physical Rehabilitation of Older Persons Following a Community-Acquired Infection Hospitalization - A Randomised-Controlled Trial

Inclusion Criteria

Exclusion Criteria

A Study of LBP-EC01 in the Treatment of Acute Uncomplicated UTI Caused by Drug Resistant E. Coli (ELIMINATE Trial)

The Fever Clinic Acute Respiratory Cohort

Evaluation of the Effectiveness and Safety of a Vaginal Gel for Prevention of Recurrent Urinary Tract Infections

Research of the Consequences on the Digestive Tract Following the Proposed Treatments for a Urinary Infection in Children

The Optimal Antibiotic Treatment Duration for Community-acquired Pneumonia in Adults Diagnosed in General Practice in Denmark (CAP-D)

Ureteral Stent Exchange Abstention in Urinary Tract Infections