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Positive Expiratory Pressure (PEP) and Continuous High-frequency Oscillation (CHFO) on Lung RECRUITment Using Electrical Impedance Tomography (EIT) - The PEP-RECRUIT Study

Effect of Continuous High-frequency Oscillation (CHFO) and Continuous Positive Expiratory Pressure (CPEP) Therapy on Lung RECRUITment Using Electrical Impedance Tomography (EIT) - The PEP-RECRUIT Study

NCT06689020•University of Genova

View on ClinicalTrials.gov

Summary

This single-center observational study aims to assess the effects of continuous high-frequency oscillation (CHFO) and continuous positive expiratory pressure (CPEP) therapy on lung recruitment using electrical impedance tomography (EIT) in spontaneously breathing patients admitted to the intensive care unit.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients who require pulmonary expansion and airway clearing as per clinical indication
•Patients who provide valid informed consent according to local regulations
•PaO2/FiO2 \< 200 mmHg at inclusion
•Patient on the Airway Care Score (ACS) \< 7

Exclusion Criteria

•Refuse to participate
•Age \< 18 years
•Hemodynamic instability, defined as systolic arterial pressure \< 90 mmHg or mean pressure \< 60 mmHg
•Contraindication to using an EIT (i.e., pacemaker or defibrillator)
•Inability to properly position the EIT device for anatomical reasons

Locations (1)

UO Clinica Anestesiologica e Terapia Intensiva, IRCCS Ospedale Policlinico San Martino

Genova, GE, Italy

Key Dates

Start Date

December 1, 2024

Primary Completion Date

June 1, 2025

Completion Date

July 1, 2025

Last Updated

November 14, 2024

Enrollment

ESTIMATED participants

Conditions

RecruitmentRespiratory Failure

Interventions

Continuous high-frequency oscillation (CHFO) and continuous positive expiratory pressure (CPEP) therapy

PROCEDURE

Contacts

Denise Battaglini, MD, PhD

CONTACT

+39-0105554970 battaglini.denise@gmail.com

Lorenzo Ball, MD, PhD

CONTACT

+39-0105554970 lorenzo.ball@unige.it

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 14, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Positive Expiratory Pressure (PEP) and Continuous High-frequency Oscillation (CHFO) on Lung RECRUITment Using Electrical Impedance Tomography (EIT) - The PEP-RECRUIT Study

Inclusion Criteria

Exclusion Criteria

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