Colorado Clinical & Translational Sciences Institute
This is an open-label, single site study in pre-menopausal women aged 18-40 years old with a history of regular menstrual cycles (25-35 days long) of normal BMI or high BMI. The objective of the study is to determine the effects of an estradiol patch on luteinizing hormone rise in both cohorts. The study consists of 2 periods: a screening period of up to 3 weeks and a Treatment Period of 7-10 days. During the treatment period participants will wear estradiol patches for up to 7 days and have on blood draw on day 3 of wearing the patches. Participants will also collect daily morning urine for all the days they wear the patches. Participants will use a reliable barrier method of birth control or abstain from intercourse for the duration of the study.
Age
18–38
Sex
FEMALE
Healthy volunteers
Accepted
You may be eligible if
Age 18-38
Regular menstrual cycles every 25-35 days
No use of reproductive hormones within the past 3 months
No use of medications interacting with reproductive hormones
Agreement to use reliable barrier contraception or to abstain from intercourse for the duration of the study
Normal thyroid stimulating hormone, prolactin and lipid profiles
No more than 4 hours of moderate to vigorous intensity exercise per week
No history of chronic disease impacting reproductive hormones
No contraindications to administration of estradiol
No history of estrogen dependent cancer
Negative pregnancy test
You may not be if
Has diabetes
Is a smoker
History of venous thromboembolism or known thrombophilia
