A Study to Investigate Weight Management With LY3549492 Compared With Placebo in Adult Participants With Obesity or Overweight

Exclusion Criteria

• •W8M-MC-GN01:
• •Have Type 2 Diabetes Mellitus or Type 1 Diabetes Mellitus
• •Have a history of acute or chronic pancreatitis
• •Have renal impairment
• •Individuals who are of childbearing potential
• •W8M-MC-CWMM:
• •Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed \>1 year prior to screening.
• •Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma.
• •Have poorly controlled hypertension.
• •Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease.
• •Have any of the following cardiovascular conditions within 3 months prior to screening:
• •* acute myocardial infarction
• •* cerebrovascular accident (stroke)
• •* unstable angina, or
• •* hospitalization due to congestive heart failure.
• •Have a history of symptomatic gallbladder disease within the past 2 years
• •Have a lifetime history of suicide attempts.