Registration Trial of the Drug-coated Balloon for the Symptomatic Cerebral Atherosclerotic Stenosis

Exclusion Criteria

• •History of acute ischemic stroke within 2 weeks;
• •Stenosis due to non-atherosclerotic lesions such as arterial dissection, Moya-Moya disease and vasculitic disease;
• •Target vessels complete occlusion or with thrombus in target vessels;
• •Target vessel with severe calcification or distortion that making interventional device is difficult to place;
• •History of stenting in the target artery;
• •Target vessel restenosis following stenting or balloon angioplasty;
• •Combined with other lesion with ≥70% stenosis in target vessel.
• •Residual stenosis ≥50% or vessel dissection with obvious blood flow restriction occurs after predilation.
• •Combined with intracranial tumour, arteriovenous malformation or aneurysm of the target vessel.
• •History of intracranial hemorrhage within 90days.
• •Presence of severe systemic diseases that cannot tolerate surgery, such as severe liver and kidney dysfunction;
• •Contraindication to the use of anticoagulants and antiplatelet agents, such as sllergy to anticoagulants and antiplatelet agents, active bleeding or coagulation disorders;
• •Allergic to contrast agents or rapamycin;
• •Pregnant or lactating women;
• •Participating or intending to participate in any other drug/device clinical trials;
• •Life expectancy \<1 year;
• •Any other conditions that the investigator deems the patient unsuitable for enrollment.