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Disorders of Sexual Development and Gonadal Tumor Risk | Clinical Trials | Clareo Health

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Disorders of Sexual Development and Gonadal Tumor Risk

DEV-GEN-RiTuGo - Assessment of Individual Gonadal Tumor Risk in Patients With Disorders of Sexual Developpment According to the Etiology.

NCT06682078•Hospices Civils de Lyon

View on ClinicalTrials.gov

Summary

Disorders of Sexual Development are rare and represent a spectrum of heterogeneous pathologies. The risk of developing a malignant gonadal germ cell tumor (MGCT) exists and varies according to the etiology. The indication for prophylactic gonadectomy must be modulated and discussed for all patients. It is essential to assess each patient's individual risk. The aim of our study is to assess gonadal tumor risk in patients with Disorders of Sexual Development according to etiology The primary objective is to evaluate tumor risk and the indication for gonadectomy in cases of Disorders of Sexual Development according to etiology. The secondary objectives are to evaluate the timing of gonadectomy, to monitor changes in practice over time, and to assess the contribution of imaging and/or biological tests to tumor detection.

Eligibility

Age

All ages

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients who underwent gonadectomy for variation in genital development between 1990 and 2022.
•Pathological anatomy examination in Lyon
•With clinical data
•With karyotype
•3 categories:
•* with genetic diagnosis
•* without genetic diagnosis because searched but not found
•* without genetic diagnosis because not searched

Exclusion Criteria

•Biopsies without gonadectomy
•Fetus
•Operated outside the period 1990-2022
•Lack of clinical data
•No karyotype

Locations (1)

Service de Chirurgie uro-viscérale pédiatrique

Bron, France

Key Dates

Start Date

September 1, 2023

Primary Completion Date

December 1, 2023

Completion Date

June 1, 2024

Last Updated

April 13, 2025

Enrollment

ACTUAL participants

Conditions

Disorders of Sexual Development

Interventions

Not applicable . Non-interventional retrospective study, only on datas.

OTHER

Retrospective Analysis of the Neonatal Management of Patients with an Antenatal Diagnosis of Genital Development Variation At the Hospital of Lyon

NCT06687252

EndocrinologyDisorders of Sexual Development+13 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 13, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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