Age

21–80

Sex

ALL

Healthy volunteers

Not accepted

Patients with diagnosis of sporadic ALS (definite or clinically probable) as defined by the World Federation of Neurology revised El Escorial criteria
SVC of 50% or greater of estimated measure and presence of measurable motor evoked potential
21 to 80 years old and male or female

patients with fALS (based on medical history) that are unable to tolerate TMS and MRI studies or have a contraindication as described below

Testing Pulse Stimulation to Improve Motor Function in People With ALS: A Pilot Study