Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Saskatchewan
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
age (years) at least 18 years
no confounding health issue (i.e. no health conditions, other than asthma, that would put the participant at risk or affect data integrity as determined by the principal investigator)
baseline FEV1 ≥ 65% of predicted normal at Visit 1
evidence of atopy to an allergen suitable for inhalation challenge following skin prick testing such as house dust mite, grass, cat or horse
fall in FEV1 of ≥ 20% at a dose of methacholine ≤ 600mcg (methacholine PD20) at Visit 1
positive response to allergen inhalation challenge (fall in FEV1 of ≥ 15% after inhalation of allergen at a dilution 1:32 or more dillute.
absence of respiratory infection for at least 4 weeks prior to Visit 1
absence of significant worsening of asthma that requires health care intervention or prolonged change in medication due to allergen exposure (or other trigger) for at least 4 weeks prior to Visit 1
women of child-bearing potential shall not be pregnant or lactating
non-smoker (cigarettes, vaping); ex-smoker with \<10 pack year history allowed; cannabis use will be evaluated on a case-by-case basis
if on as needed budesonide/formoterol therapy, no reported use within 3 weeks prior to allergen challenge
You may not be if
Smoker \>10 pack year history
Clareo Health | Evaluating the Impact of Single Dose Tiotropium on Allergen-induced Early Asthmatic Response
