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Individual Factors of CBT Underlying Success | Clinical Trials | Clareo Health

RECRUITINGNA

Individual Factors of CBT Underlying Success

Contributions of Self-Focused Attention to Early Warning Indicators of Cognitive Behavioral Therapy Non-Response

NCT06678295•University of Washington

Summary

The purpose of this study is to understand why some individuals respond fully to cognitive behavioral therapy and others do not, based on multiple sources of data such as neural, neurocognitive, clinical, and self-report data.

Detailed Description

The investigators are conducting this research to evaluate the reliability and construct validity of measures of self-focused attention (SFA) across neural, neurocognitive, and self-report levels of analysis as well as examine whether early changes in the SFA biomarker are associated with CBT non-response. This will be looked at in a clinical population consisting of individuals with social anxiety disorder (SAD) and body dysmorphic disorder (BDD) compared to healthy volunteers. This study employs an open clinical trial for cognitive behavioral therapy with pre-, mid- and post-treatment neuroimaging scans, clinical interviews, neurocognitive, behavioral, and self-report assessments. Clinical participants will be invovled for 3.5 months and complete 12 CBT sessions and 4 fMRI scans. Control participants will not participate in CBT treatment and will complete 3 fMRI scans across a 3.5 month period. About 160 people will take part in this research study, all at the University of Washington (UW). This will include 110 clinical participants and 50 healthy control participants.

Eligibility

Age

18 - 45 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Clinical sample (N=110):
•1. Men and women, age 18-45
•2. Treatment-seeking individuals who meet criteria for a primary DSM-5 diagnosis of primary social anxiety disorder (SAD) or body dysmorphic disorder (BDD) based on the SCID-5-RV
•3. Fluent in English and willing to provide informed consent.
•Control sample (N=50):
•1. Men and women, age 18-45
•2. No current or lifetime history of psychiatric disorders, as assessed using the SCID-5-RV
•3. Meet criteria for low levels of anxiety (GAD-7 score of \<8) and depression (PHQ-9 score \<10)
•4. Fluent in English and willing to provide informed consent

Exclusion Criteria

•All groups:
•1. Score \< 80 based on WRAT5 Word Reading Subtest
•2. fMRI contraindications (e.g., electronic medical devices such as pacemakers, implanted defibrillators, etc.; metal implants not approved for MRI; pregnancy; claustrophobia)
•2\. Active suicidal or homicidal ideation, or any features requiring a higher level of care 3. Lifetime history of manic or hypomanic episode, psychotic symptoms, traumatic brain injury, neurological disorder, pervasive developmental disorder, or attention deficit-hyperactivity disorder; active alcohol or substance use disorder in the past 6 months 4. Current use of psychotropic medications, except antidepressants taken at a stable dose for 3 months prior to study baseline 5. Previous CBT non-responder or current CBT

Locations (1)

University of Washington

Seattle, Washington, United States

Key Dates

Start Date

October 15, 2024

Primary Completion Date

September 30, 2028

Completion Date

September 30, 2028

Last Updated

February 17, 2026

Enrollment

160

ESTIMATED participants

Conditions

Social Anxiety DisorderBody Dysmorphic Disorder

Interventions

Cognitive Behavioral Therapy

BEHAVIORAL

Contacts

Angela Fang, PhD

CONTACT

(206) 616-5783 angfang@uw.edu

ACTsocially: The (Dis)Similarities of ACT for Changing Internalizing and Externalizing Symptomatology in Adolescence

NCT07456631

Social Anxiety Disorder (SAD)Oppositional Defiant Disorder

View study

RECRUITINGNA

Internet-Delivered Cognitive Behavioral Intervention for Youths With Anxiety Disorders

NCT06661460

ANXIETY DISORDERS (or Anxiety and Phobic Neuroses)Specific Phobia+5 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 17, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Individual Factors of CBT Underlying Success

Inclusion Criteria

Exclusion Criteria

ACTsocially: The (Dis)Similarities of ACT for Changing Internalizing and Externalizing Symptomatology in Adolescence

Internet-Delivered Cognitive Behavioral Intervention for Youths With Anxiety Disorders

Comparing TBT to Disorder-Specific Psychotherapy in Veterans With Social Anxiety Disorder

Application of Virtual Reality Technology to Treatment of Social Anxiety

CBT Effects on Neurophysiological and Psychological Outcomes in Body Dysmorphic Disorder

Intervention Social Anxiety: Combining Parent-child Treatment