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COMPLETEDNCT06674070

SCN2A Polymorphisms Are Associated With Response to Valproic Acid in Paediatric Population(Pakistan)

The goal of this Observational study was to identify the effect of SCN2A gene polymorphism in the Paediatric epileptic Pakistani population. The main question it aims to answer is: to evaluate the ef...

Lead sponsor: Riphah International University•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Riphah International University

This observational study aimed to identify the effect of SCN2A rs2304016 gene polymorphism in the Paediatric epileptic population. The main question it aims to answer is: • to evaluate the effect of this genetic polymorphism on the clinical efficacy of Valproic acid The participants' blood samples were taken and further genotyping was performed using conventional tetraARMS PCR. The results were visualized by gel electrophoresis.

Age

0 - 12 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Epileptic Pakistani individuals of age between 1 to 12 years of either sex
•Each patient had experienced two or more clinically confirmed, spontaneous epileptic seizures in the past.
•Newly diagnosed patients started VPA 20 mg/kg (drug of the same brand was used for every patient throughout the study).

Exclusion Criteria

•Patients taking any other anti-epileptic drug.
•Patients taking medications that interact with VPA.
•Patients with moderate or severe systemic diseases

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: November 5, 2024Terms

Trial snapshot

StatusCOMPLETED

Phase—

Enrollment200

Start dateDec 2023

Last updatedNov 5, 2024

Condition

Locations shown

IIMC, Riphah International University

Islamabad, Federal

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 5, 2024Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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