A Study to Confirm Efficacy and Safety of HS-10374 for Moderate to Severe Plaque Psoriasis

Exclusion Criteria

• •Diagnosis of non-plaque psoriasis or drug-induced psoriasis
• •Recent history of infection, history or risk of serious infection
• •Any major illness or evidence of unstable condition of major organ systems including psychiatric disease
• •Any condition possibly affecting the PK process of the study drug
• •Evidence of other skin conditions that would interfere with the evaluation of psoriasis
• •History of hypersensitivity to the ingredients of study drugs, history of anaphylaxis
• •Prior exposure to TYK2 inhibitors
• •Have received the prohibited treatment during the protocol required washout period
• •Any significant laboratory or procedure abnormalities that might place the subject at unacceptable risk during this study period