Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

Diagnosis of CKD stage 5D, maintenance hemodialysis not less than 3 months prior screening;
Moderate-to-severe pruritis (WI-NRS score ≥ 4);
Adequate dialysis dose (spKt/V≥1,4 and/or eKt/V≥1,2);
Dialysis treatment regimen: three sessions per week of at least 4 hours duration;
Signed informed consent.

Presence of active skin disease, cholestasis, severe secondary hyperparathyroidism and other conditions that, in the investigator's opinion, may be responsible for pruritus.
Noncompliance of the patient with the protocol (in the investigator's opinion).
Use of haemodiafiltration.

Effect of Kidney Replacement Therapy with Polymethylmethacrylate Membranes on Pruritus-related Quality of Life in Patients Receiving Maintenance Haemodialysis