Bone Properties Following Exercise Induced Changes in Insulin Sensitivity in People With Type 2 Diabetes

Exclusion Criteria

• •Recent substantial changes in diet (within 3 months)
• •Recent substantial changes in activity level (within 3 months)
• •Recent substantial weight changes (within 3 months)
• •Current or previous treatment (within the last 2 years) with non-oral anti-diabetics or oral GLP-1 analogs
• •HbA1c ≥ 90 mmol/mol
• •HbA1c \< 48 mmol/mol without anti-diabetic medication
• •Premature menopause (menopause before 40 years of age)
• •Current pregnancy
• •Treatment with one of the following medications:
• •* Systemic glucocorticoids (within the last 2 years)
• •* Antiresorptive or bone anabolic medication (ever)
• •* Lithium (ever)
• •* Anticonvulsive medication (current)
• •* Menopausal replacement therapy (currently)
• •Estimered glomerular filtrationsrate (eGFR) \< 60 mL/minutes
• •High level of physical activity, assessed by the investigators to interfere with the study results
• •Substantial cardiovascular, endocrine, renal, hepatic, rheumatological, gastrointestinal or other disorders assessed by the investigator
• •Electronic implants
• •Osteoporosis or other bone disease
• •Resent bone fracture (within 6 months)
• •Previous bone fracture in either both tibial bones or both radial bones
• •Parathyroid or calcium metabolism disorder
• •Vitamin D deficiency (\< 50 nmol/L)
• •Other substantial medical disorder in unstable phase or active cancer within the last five years except spino- or basocellular carcinoma
• •Lack of ability to complete the intervention
• •Patients assessed uneligible by the investigator to participate in the study