Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Merck Sharp & Dohme LLC
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Has documented diagnostic Right Heart Catheterization, with the diagnosis of World Health Organization (WHO) Pulmonary Atrial Hypertension (PAH) Group 1 in any of the following subtypes: Idiopathic PAH, Heritable PAH, Drug/toxin-induced PAH, PAH associated with connective tissue disease, PAH associated with simple, congenital systemic-to-pulmonary shunts at least 1 year following repair
Has symptomatic PAH classified as WHO Functional Class II or III
You may not be if
Has a weight of \<35 kg
Has a diagnosis of PH WHO Groups 2, 3, 4, or 5
Has a diagnosis of the following PAH Group 1 subtypes: HIV-associated PAH, PAH associated with portal hypertension, Exclusion in PAH Group 1 should also include schistosomiasis-associated PAH, pulmonary veno occlusive disease and pulmonary capillary hemangiomatosis
Has uncontrolled systemic hypertension
Has a history of pneumonectomy
Has a history of known pericardial constriction
Has a history of restrictive cardiomyopathy
Has history of atrial septostomy (within 180 days prior to study start)
Has personal or family history of long QT syndrome
Has history of coronary artery disease (myocardial infarction, percutaneous coronary intervention, coronary artery bypass, graft surgery, or cardiac anginal chest pain) (within 6 months prior to study start)
Has a cerebrovascular accident (within 3 months prior to study start)
Has significant (\>2+ regurgitation) mitral regurgitation or aortic regurgitation valvular disease
Has untreated more than mild obstructive sleep apnea
Has known malignancy that is progressing or has required active treatment within the past 5 years
Has recently started (within 12 months prior to study start) or has plans to start weight loss medication or enter a weight loss program during the study period
Has a previous (within 3 years) or planned (during the study) obesity treatment with surgery or a weight-loss device
