A Study to Evaluate ALN-6400 in Healthy Volunteers and Patients With Hereditary Hemorrhagic Telangiectasia (HHT)

Exclusion Criteria

• •Part A:
• •Has alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \> upper limit of normal (ULN)
• •Has known human immunodeficiency virus (HIV) infection; or known current or chronic hepatitis C virus or hepatitis B virus infection
• •Has an estimated glomerular filtration (eGFR) of \<90 mL/min/1.73m\^2 at screening
• •Part B:
• •Has ALT or AST \>2×ULN
• •Has total bilirubin \>1.5×ULN
• •Has eGFR of \<30 mL/min/1.73m\^2 at screening
• •Parts A and B:
• •Is not willing to comply with the contraceptive requirements during the study period