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Enabling Microbiomics- Driven Personalized Nutrition | Clinical Trials | Clareo Health

ENROLLING_BY_INVITATION

Enabling Microbiomics- Driven Personalized Nutrition

Enabling Microbiomics- Driven Personalized Nutrition (EMPOWER)

NCT06657001•Mayo Clinic

Summary

The goal of this observational research study is to determine how diet contributes to various gastrointestinal related conditions. The main question investigators aim to answer is: Are host genetics, diet, and microbiome all important determinants of GI disorders, and how their relative contribution varies among individuals and populations.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Age greater than or equal to 18 years
•Gastrointestinal patients with or without genomic sequencing results available for the following cohorts:
•* Inflammatory Bowel Disease (IBD)
•* Irritable Bowel Syndrome (IBS)
•* Crohn's Disease
•* Celiac Disease
•* Diarrhea
•* Constipation
•Healthy age and sex matched controls with or without genomic sequencing results available
•o Control is defined as patients without gastrointestinal disease or no symptoms at time of sampling
+2 more criteria

Exclusion Criteria

•Patients with cognitive impairment
•Active use of antibiotics at the time of stool collection

Locations (1)

Mayo Clinic

Rochester, Minnesota, United States

Key Dates

Start Date

March 28, 2025

Primary Completion Date

September 1, 2026

Completion Date

April 1, 2027

Last Updated

June 25, 2025

Enrollment

4,001

ESTIMATED participants

Conditions

Inflammatory Bowel Disease (IBD)Irritable Bowel Syndrome (IBS)Celiac DiseaseDiarrheaConstipationMicrobiomeCrohn's DiseaseUC - Ulcerative ColitisMicroscopic ColitisFunctional Dyspepsia

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Irritable Bowel Syndrome (IBS)

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GF-NOURISH (Gluten Free Nutrition Optimization Through Ultra-processed Food Reduction and Improved Strategies for Health)

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 25, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Enabling Microbiomics- Driven Personalized Nutrition

Inclusion Criteria

Exclusion Criteria

Safety and Efficacy of Lyophilized Faecal Microbiota Transplantation Via Capsules in Treatment of Irritable Bowel Syndrome

Study of DONQ52 in Active Celiac Disease

GF-NOURISH (Gluten Free Nutrition Optimization Through Ultra-processed Food Reduction and Improved Strategies for Health)

Hydroxyapatite-Based Home Treatment for Dentin Sensitivity in Celiac Patients

Switching to the IL-23 Inhibitor Guselkumab for People With Active IBD Who Previously Used Ustekinumab (SHIFT-IBD)

Prophylactic Dexamethasone Before Infliximab in Moderate-to-Severe IBD