Efficacy and Safety of a Two-week Dosing Regimen of Vinorelbine Combined with Liposomal Doxorubicin in the Treatment of HER2-negative Advanced Breast Cancer

Exclusion Criteria

• •1. There is a third interstitial fluid accumulation that cannot be controlled by drainage or other methods (such as a large amount of hydrothorax and ascites).
• •2. Symptomatic or uncontrolled brain or meningeal metastases.
• •3. Patients with only bone or skin metastasis as the assessable lesion.
• •4. Previously suffered from other malignant tumors.
• •5. Those who have used vinorelbine or Pegylated Liposomal Doxorubicin during the advanced disease stage.
• •6. Individuals with a known history of allergies to the components of the interventions; History of immunodeficiency, including HIV positive, other acquired or congenital immunodeficiency diseases and a history of organ transplantation.
• •7. Any heart disease or other conditions evaluated unsuitable by the researcher.
• •8. Pregnant and lactating female patients, female patients with fertility and positive baseline pregnancy test results, or female patients of reproductive age who are unwilling to take effective contraceptive measures throughout the trial period.
• •9. According to the investigator\'s judgment, there are concomitant diseases that seriously endanger the patient\'s safety or affect the patient\'s completion of the study (including severe bleeding tendency, history of surgery within 2 weeks, hypertension beyond drug control, serious diabetes, active infection, thyroid disease, etc.).
• •10. Having a clear history of neurological or mental disorders, including epilepsy or dementia.
• •11. According to the RECIST 1.1 criteria, researchers determined that patients who received the last anti-tumor regimen before enrollment did not experience disease progression.
• •12. Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) validated human epidermal growth factor receptor 2 (HER2) positive.