Participants with Mild to Moderate Hidradenitis Suppurativa Will Receive EVO101 a Topical Cream 0.1%

Exclusion Criteria

• •1. Very severe, severe, minimal, or clear hidradenitis suppurativa Hidradenitis Suppurativa Physician's Global Assessment scale (HS-PGA).
• •2. Women who are pregnant (or who are considering pregnancy) or breastfeeding.
• •3. Subject has uncontrolled, clinically significant comorbidities that make them unsuitable for the clinical trial in the opinion of the investigator.
• •4. Have undergone significant trauma or major surgery (per investigator's assessment) within 30 days preceding the screening visit.
• •5. History of clinically significant (per investigator's judgment) drug or alcohol abuse within 6 months preceding the screening visit.
• •6. Use of any of the following medications or treatments within the specified time periods prior to the baseline visit:
• •1. \< 12 weeks or 5 half-lives (whichever is longer)
• •* Investigational or experimental treatments.
• •* Immunomodulating biologic drugs
• •2. \< 4 weeks
• •* Systemic JAK inhibitors.
• •* Systemic immunosuppressive or immunomodulating small-molecule drugs (eg, corticosteroids \[oral or intravenous\], avacopan, IRAK4 inhibitors, methotrexate, cyclosporine, dapsone, azathioprine).
• •* Surgical, laser, or any phototherapy intervention in areas with HS lesions
• •3. \< 2 weeks
• •• Other systemic therapies for HS
• •* Retinoids, antihyperglycemics, and antiandrogens, such as acitretin, isotretinoin, metformin, spironolactone, and finasteride) with potential therapeutic impact unless the subject is on a stable dose as defined by the investigator for at least 28 days. There should be no anticipated change of these medications while the subject is on the study.
• •• Systemic anti-infectives for HS
• •* Antibiotics, antivirals, antifungals
• •4. \<1 week
• •* Oral or topical PDE4 inhibitor (e.g., apremilast, crisaborole)
• •* Topical JAK inhibitor
• •* Topical anti-infectives for HS lesions
• •o Antibiotics, antivirals, antifungals
• •* Topical products containing chlorhexidine gluconate, benzoyl peroxide, or topical diluted bleach bath to treat HS. Note: Non-medicated over-the-counter soap and water are not restricted.
• •* Any topical drug applied onto HS lesions
• •* Topical or intralesional corticosteroids o Note: Use of topical corticosteroids for dermatologic diseases other than HS (Hidradenitis Suppurativa)(e.g., atopic dermatitis, psoriasis) is allowed for areas not being treated for HS (Hidradenitis Suppurativa)as long as it is not within 10cm of the areas affected by HS (Hidradenitis Suppurativa).
• •Inhaled corticosteroids are allowed.
• •7. Active participation in an experimental therapy study or who received experimental therapy within 30 days or 5 half-lives (whichever is longer) before Baseline.