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Evaluation and Comparison Between General Anesthesia VS Two Types of Combined Anesthesia (general and Spinal Anesthesia) for Opioid Consumption in Laparoscopic Hysterectomy: a Multi-Center, Randomized, Prospective, Controlled Trial
The aim of the study is to evaluate and compare general anesthesia VS two types of combined anesthesia in opioid consumption after laparoscopic hysterectomy
Managing post-operative pain is essential to reduce length of stay, complications, mortality, healthcare costs and the risk of readmission to hospital. At the same time, pain treatment, especially with opiod drugs, could cause side effects and worsen the quality of post-operative hospitalization. Furthermore, intrathecal fentanyl may cause an acute tolerance to opioids, and may worsen postoperative analgesia. In literature, some studies underline how the use of regional anesthesia represents an effective solution in pain control. The goal of this study would be to determine whether post-operative analgesic needs and pain levels are increased by mixing intrathecal fentanyl with spinal anesthesia and intrathecal morphine.
Age
18 - No limit years
Sex
FEMALE
Healthy Volunteers
No
Ente Ospedaliero Cantonale ORBV
Bellinzona, Switzerland, Switzerland
Ente Ospedaliero Cantonale, Ospedale Regionale di Bellinzona e Valli
Bellinzona, Switzerland, Switzerland
Start Date
November 1, 2024
Primary Completion Date
April 30, 2026
Completion Date
April 30, 2026
Last Updated
February 28, 2025
45
ESTIMATED participants
General Anesthesia (control group)
PROCEDURE
General Anesthesia + Spinal anesthesia combined (local anesthetic, morfine and no fentanyl)
PROCEDURE
General Anesthesia + Spinal anesthesia combined (local anesthetic, morfine and 20 mcg fentanyl)
PROCEDURE
Lead Sponsor
Andrea Saporito
NCT07362680
NCT07326683
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and ConditionsNCT07226375