Andres M Pascual, DDS, PhD

CONTACT

Juan M Aragoneses, MD, DDS, PhD

CONTACT

Lead Sponsor

Andres Matteo Pascual La Rocca

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Yes

•adult patients with ≥18 years of age. ability to understand all the study procedures and to comply with them throughout the entire study period. Ability and willingness to give written informed consent.
•an adequate level of oral hygiene (plaque index ≤ 25%) (O\'Leary et al., 1972).
•an adequate general bleeding on probing (≤ 20%) treated periodontal disease. presence of two or more adjacent Cairo type I or II gingival recessions, with ≥1mm of keratinized gingiva in all the deffects.

•untreated periodontitis.
•smokers \> 5 cigarettes per day.
•local or systemic diseases that would interfere with routine periodontal therapy (i.e., uncontrolled diabetes mellitus, cancer, HIV, chronic high-dose steroid therapy, metabolic bone disease, radiation, immunosuppressive disease, hepatic dysfunction, immunosuppressive disease, autoimmune disease).
•treatment with anticoagulants or bisphosphonates.
•pregnant or lactating women.
•radiographic interproximal bone loss.
•tooth Mobility. If present, splinting should be performed prior to treatment.
•Active orthodontic treatment
•allergy or intolerance to study medication
•use of systemic antibiotics during the last 3 months
•use of systemic antibiotics for endocarditis prophylaxis
•patients with intentions to change residence that prevent follow-up