Reduction of Postoperative Radiotherapy in Head and Neck Squamous Cell Carcinoma

Inclusion Criteria

• •Preoperative pathologically confirmed initial treatment of head and neck squamous cell carcinoma
• •Receive neoadjuvant chemotherapy combined with PD-1 monoclonal antibody immunotherapy, and meet one of the following conditions: Preoperative clinical stage was T3-T4 or N2-N3 (AJCC 8th edition). Patients with oral cancer/oropharyngeal cancer had positive lymph nodes in the IV/V region with imaging diagnosis or biopsy confirmation before surgery. HPV/ P16-positive oropharyngeal cancer patients with clinical lymph node invasion (ENE), one positive cervical lymph node \> 3cm or multiple positive cervical lymph nodes before surgery
• •The pathology of at least one cervical lymph node was determined by pCR；
• •Karnofsky's physical status score ≥70 points；
• •Age: 18 \~ 70 years old；
• •Laboratory examination results within 1 week before enrollment met the following conditions: neutrophils (ANC) ≥1.5×109/L, platelets (PLT) ≥ 75×109/L
• •Patients participate voluntarily and sign informed consent forms.