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Use of Shear Wave Elastography for Intraoperative Brain and Tumor Stiffness Measurements | Clinical Trials | Clareo Health

NOT_YET_RECRUITING

Use of Shear Wave Elastography for Intraoperative Brain and Tumor Stiffness Measurements

NCT06630338•Mayo Clinic

View on ClinicalTrials.gov

Summary

This study investigates the role of intraoperative shear wave elastography ultrasound (ISWEU) in identifying healthy brain and tumor tissue stiffness differences. This data may be used to guide tumor resection in future patients.

Detailed Description

PRIMARY OBJECTIVE: I. Determine the feasibility of utilizing ISWEU measurements intraoperatively and in the human brain to measure tissue stiffness. OUTLINE: This is an observational study. Patients undergo shear wave elastography ultrasound over 10-15 minutes during their standard of care surgery on study.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients must be at least 18 years old.
•Patients must have planned surgery for resection of a newly diagnosed or recurrent brain tumors.
•Patients with tumors located in the brain cortex or superficial white matter in which introduction of the ultrasound probe is straightforward and does not pose a risk for intraoperative complications.
•Patients must have a Karnofsky performance status ≥ 60%.
•Patient or legally authorized representative (LAR) willing to provide written informed consent.

Exclusion Criteria

•Patients with deep-seated brain tumors in which introduction of the ultrasound probe poses an increased risk.
•Patients with a history of any brain infections.
•Patients with implanted devices.
•Patients with any other neurological/neurosurgical disease that could affect tissue stiffness.
•Patients with any other structural brain defect that could affect tissue stiffness.

Locations (1)

Mayo Clinic in Florida

Jacksonville, Florida, United States

Key Dates

Start Date

June 1, 2026

Primary Completion Date

June 28, 2033

Completion Date

June 28, 2033

Last Updated

October 14, 2025

Enrollment

ESTIMATED participants

Conditions

Brain TumorRecurrent Brain TumorBrain NeoplasmRecurrent Brain Neoplasm

Interventions

Non-Interventional Study

OTHER

Contacts

Clinical Trials Referral Office

CONTACT

855-776-0015 mayocliniccancerstudies@mayo.edu

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 14, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Use of Shear Wave Elastography for Intraoperative Brain and Tumor Stiffness Measurements

Inclusion Criteria

Exclusion Criteria

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