Effectiveness and Safety of Probiotics in Relieving Anxiety and Depression

Exclusion Criteria

• •1. Past Diagnosis of Certain Conditions: Individuals with a history of other clearly diagnosed psychiatric disorders, intellectual disabilities, consciousness disorders, complete aphasia, bipolar disorder, treatment-resistant depression, or suicidal thoughts.
• •2. Pregnant or Breastfeeding Women: Individuals who are pregnant or breastfeeding.
• •3. Use of Certain Medications: Individuals who have used anti-anxiety, anti-depressant medications, or mood stabilizers within the past month.
• •4. Allergy History: Individuals with allergic constitutions or a history of drug allergies, or those with severe systemic diseases.
• •5. Substance Abuse History: Individuals with a history of alcohol or psychoactive substance abuse within the past 3 months.
• •6. Impact of Medications on Gut Microbiota: Individuals who have used medications affecting gut microbiota (including antibiotics, probiotics, mucosal protectors, traditional Chinese medicine, etc.) continuously for more than 1 week in the month prior to screening.
• •7. Discontinuation or Addition of Medications: Individuals who have stopped taking the study medication or started taking other medications, making it difficult to assess efficacy or with incomplete data.
• •8. Use of Similar Products: Individuals who have taken items similar to the study product in the short term, affecting the evaluation of results.
• •9. Inability to Participate: Research participants who cannot participate in the study due to personal reasons.
• •10. Other Exclusions: Participants deemed unsuitable for the study by the researchers.