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Screening for Prostate Cancer Using High Resolution Micro-ultrasound Versus Multiparametric Magnetic Resonance Imaging. | Clinical Trials | Clareo Health

RECRUITINGPHASE3

Screening for Prostate Cancer Using High Resolution Micro-ultrasound Versus Multiparametric Magnetic Resonance Imaging.

A Phase 3, Multicenter, International, Non-inferiority, Randomized Clinical Trial Comparing Screening for Prostate Cancer Using High Resolution Micro-ultrasound Versus Multiparametric Magnetic Resonance Imaging (MUSIC-Screen)

NCT06626022•University of Alberta

View on ClinicalTrials.gov

Summary

The purpose of this study is to compare whether the FDA and Health Canada approved microUS is as effective as the currently used option (MRI) for imaging the prostate gland. Participants will be randomized into two groups to compare the imaging results of the current standard of care MRI and the new microUS. The study is looking to identify the most effective imaging modality to help guide whether you progress to have a prostate biopsy.

Eligibility

Age

50 - 70 years

Sex

MALE

Healthy Volunteers

Yes

Inclusion Criteria

•1. Male sex;
•2. Age 50-70;
•3. PSA 3-20 and/or abnormal DRE;
•4. Biopsy naïve.

Exclusion Criteria

•1. Prior personal history of prostate cancer;
•2. Prior prostate imaging using microUS or MRI;
•3. Contraindication to microUS or MRI;
•4. Testosterone replacement therapy within last 12 months; or
•5. Androgen deprivation therapy within last 12 months.

Locations (5)

University of California, Los Angeles (UCLA)

Los Angeles, California, United States

University of Alberta

Edmonton, Alberta, Canada

University of British Columbia

Vancouver, British Columbia, Canada

CIUSSS du Nord-de-l'Île-de-Montréal

Montréal, Quebec, Canada

Urologia Clinica Bilbao

Bilbao, Spain

Key Dates

Start Date

May 8, 2025

Primary Completion Date

November 30, 2029

Completion Date

November 30, 2029

Last Updated

March 12, 2026

Enrollment

1,284

ESTIMATED participants

Conditions

Prostate Cancer Screening

Interventions

MRI

DEVICE

ExactVu

DEVICE

Contacts

Adam Kinnaird, MD, PhD

CONTACT

+1-780-407-5800 ask@ualberta.ca

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 12, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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