Comparison of the Efficacy of Ultrasound-Guided Injections of Saline, High-Concentration Dextrose, and Ligament Repair Agents for the Treatment of Medial Collateral Ligament Pathology in Degenerative Knee Osteoarthritis: A Randomized Double-Blind Trial.

Ting-an Chen

CONTACT

Lead Sponsor

Chen Ting-an

Age

45 - 80 years

Sex

ALL

Healthy Volunteers

No

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•The patients should fulfill the following criteria:
•1. Age between 45 to 80 years old.
•2. Meet at least three of the six American College of Rheumatology (ACR) criteria, including age over 50 years, morning stiffness less than 30 minutes, crepitus in passive knee movements, bony tenderness, bony enlargement, and no palpable warmth.
•3. Radiologic grading of 2 or 3 according to Kellgren-Lawrence criteria.
•4. Evidence of medial collateral ligament (MCL) pathology with incomplete injuries (grade I or II).
•5. Willing to receive prolotherapy treatment.
•6. Willing and able to complete all follow-ups and assessments in the randomized double-blind trial.

•1. Severe systemic disorders including cancer, uncontrolled diabetes mellitus, sepsis, or cardiopulmonary diseases.
•2. History of anticoagulation therapy, knee injection over the past three months.
•3. History of knee surgery or candidates for knee arthroplasty.
•4. History of intolerance to prolotherapy.
•5. Pregnancy.
•6. Infectious arthritis, inflammatory joint diseases, joint dysplasia.
•7. Body Mass Index (BMI) greater than 35 kg/m2.
•8. Complete tear of medial collateral ligament under ultrasound.
•9. Fracture or other causes of knee pain instead of osteoarthritis.