Finding studies
Finding studies
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Hopkins GYN Trials
CONTACT
Sidney Kimmel Cancer Center Clinical Research Office
CONTACT
Lead
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
With
This is a single-arm phase 2, two-stage, non-randomized multicenter Phase 2 study designed to evaluate the clinical activity (response frequency) of senaparib and temozolomide (TMZ) in patients with recurrent or persistent clear cell or endometrioid ovarian cancer. Up to 18 adult female subjects will be enrolled and receive senaparib 80mg orally daily Days 1-28 and TMZ 20mg daily Days 1-21 of a 28 day cycle. Tumor assessments will be performed every 8 weeks for first 3 cycles then every 12 weeks thereafter until progressive disease is confirmed. Treatment will continue until either unacceptable toxicity, progression of disease, or withdrawal of consent.
Age
18–any
Sex
FEMALE
Healthy volunteers
Not accepted