Loading clinical trials...

COMPLETED

Lung Hyperinflation and Response to Pulmonary Vasodilator Therapy

Impact of Lung Hyperinflation on the Response to Pulmonary Vasodilator Therapy in Patients with Pulmonary Hypertension (PH) Associated with Chronic Obstructive Pulmonary Disease (COPD).

NCT06613321•Central Hospital, Nancy, France

View on ClinicalTrials.gov

Summary

The goal of this retrospective observational study is to evaluate if lung distension disorders can be a predictive factor of bad response to vasodilator therapy in patients with pulmonary hypertension (PH) associated with chronic obstructive pulmonary disease (COPD). The study will include all patients from the hospital, followed for pulmonary hypertension associated with COPD under vasodilator therapy between 2015 and 2021.

Detailed Description

The goal of this retrospective observational study is to evaluate if lung distension disorders can be a predictive factor of bad response to vasodilator therapy in patients with pulmonary hypertension (PH) associated with chronic obstructive pulmonary disease (COPD). The study will include all patients from the hospital, followed for PH associated with COPD under vasodilator therapy between 2015 and 2021. It will evaluate patients' lung hyperinflation according to the RV/TLC ratio and their response to treatment.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients with COPD regardless of severity defined as a FEV1/FVC ratio less than 0.70 and the presence of a risk factor (smoke exposure with at least a 10 pack-year history, or professional exposition) diagnosed with PH according to ESC/ERS 2022 classification and in whom vasodilator therapy has been initiated

Exclusion Criteria

•other known concomitant lung disease (interstitial lung disease, cystic lung disease, mucoviscidosis…)
•thoracic pathology such as kyphoscoliosis
•pleural effusion (unless part of pulmonary veno-occlusive disease)
•a large tumor lung mass
•EFR missing or uninterpretable because difficult to perform
•initiation of calcium channel blockers
•surgical treatment in chronic thrombo-embolic pulmonary hypertension
•no follow-up evaluation (lost to follow-up or died before reassessment)

Locations (1)

CHU Nancy

Vandœuvre-lès-Nancy, France

Key Dates

Start Date

August 1, 2023

Primary Completion Date

March 25, 2024

Completion Date

March 25, 2024

Last Updated

September 25, 2024

Enrollment

ACTUAL participants

Conditions

CopdHypertension, PulmonaryHyperdistention

Interventions

Respiratory function tests before introduction of vasodilator therapy

DIAGNOSTIC_TEST

3 month follow up evaluation of response to treatment.

DIAGNOSTIC_TEST

cfMSC Stem Cell Therapy Targeting COPD

NCT07477600

Chronic Obstructive Pulmonary Disease (COPD)

View study

RECRUITINGNA

Effect of Telenursing on Oral Health

NCT07462221

COPD

View study

RECRUITINGNA

Emotional-distress-based Integrated Care Programme in Patients With an Acute Exacerbation of COPD

NCT07351929

COPD Exacerbation

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 25, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Lung Hyperinflation and Response to Pulmonary Vasodilator Therapy

Inclusion Criteria

Exclusion Criteria

cfMSC Stem Cell Therapy Targeting COPD

Effect of Telenursing on Oral Health

Emotional-distress-based Integrated Care Programme in Patients With an Acute Exacerbation of COPD

Probiotics in Pulmonaty Rehabilitation for COPD

A Deep-Learning-Enabled Electrocardiogram for Detecting Pulmonary Hypertension

Effects of Eccentric Exercise Training in Patients With COPD